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Series : Frontiers in Nanobiomedical Research

Handbook of Immunological Properties of Engineered Nanomaterials
全3巻

Handbook of Immunological Properties of Engineered Nanomaterials 全3巻
Author
Dobrovolskaia, Marina A. (EDT)/ McNeil, Scott E. (EDT) 
Publisher
World Scientific 
Publication Date
May, 2016 
ISBN
9814699160 or 9789814699167
HARDCOVER 
900 Pages
出版済み 3-5週間でお届けいたします。
The delivery time takes 3 to 5 weeks

¥ 102,462 (tax included)

Description

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第1巻:免疫毒性の研究に先立ち、ナノ粒子の特性についての留意点
第2巻:人工ナノ物質の血液適合性について
第3巻:人工ナノ物質と免疫細胞の機能について

医療に応用される人工ナノ物質の免疫に関連した論文のレビュー、ケース/スタディー、実験の実施要項など包括的にとりあげている。若手研究者からエキスパートまでナノ免疫毒性を研究するすべての人に役立つ情報源となっている。著者の人工ナノ物質の前床研究で培われた豊富な経験を読者は共有することができる。

This unique book provides comprehensive overview of the field of immunology related to engineered nanomaterials used for biomedical applications. It contains literature review, case studies and protocols. The book can serve as a source of information about nanoimmunotoxicology for both junior scientists and experts in the field. The authors have more than 10 years of experience with preclinical characterization of engineered nanomaterials used for medical applications, and they share their experience with the readers. In addition, the international team of experts in the field provides the opinion and share the expertise on individual topics related to nanoparticle physicochemical characterization, hematocompatibility, and effects on the immune cell function . The second edition contains updated chapters from the first edition plus new chapters covering areas of tumor immunology, nanoparticle interaction with lymphatic system, mathematical modeling of protein corona, utilization of nanoparticles for the delivery of antiviral drugs, extensive analysis of nanoparticle anti-inflammatory and immunosuppressive properties, novel ways of protecting therapeutic nanoparticles from the immune recognition, as well as case studies regarding nanoparticle sterilization, complement activation, protein binding and immunotherapy of cancer. The second edition comes in 3 volumes. Volume 1 is focused on nanoparticle characterization, sterility and sterilization, pyrogen contamination and depyrigenation. It also contains overview of regulatory guidelines, protocols for in vitro and in vivo immunotoxicity studies, and correlation between in vitro and in vivo immunoassays. Volume 2 is focused on hematocompatibility of nanomaterials. It provides comprehensive review and protocols for investigating nanoparticle interaction with erythrocytes, platelets, endothelial cells, plasma coagulation factors and plasma proteins forming so called "corona" around nanoparticles. Volume 3 is dedicated to nanoparticle interaction with and effects on the immune cell function. It also contains examples of nanoparticle use for delivery of antiviral and anti-inflammatory drugs.

Contents

Volume 1: Key Considerations for Nanoparticle Characterization Prior to Immunotoxicity Studies:
Immunological Properties of Engineered Nanomaterials: An Introduction (Dobrovolskaia MA & Mcneil SE)
Importance of Physicochemical Characterization Prior to Immunological Studies (Clogston JD & Patri AK)
Nanoparticle Sterility and Sterilization of Nanomaterials (Subbarao N)
Sterilization Case Study 1: Consequences of Different Sterilization Techniques on Gold Nanoparticles (Gonzalez-Fernandez A et al.)
Sterilization Case Study 2: Effects of Sterilization Techniques on Silver Nanoparticles (Dobrovolskaia MA et al.)
Surface Contaminants and Their Role in Nanoparticle Immunotoxicity (Grainger D et al.)
Endotoxin and Engineered Nanomaterials (Dobrovolskaia MA & Mcneil SE)
Endotoxin Case Study: Nanoparticle Interference with Gel-Clot LAL (Kraegeloh A et al.)
Regulatory Considerations (Weaver J. et al.)
In Vitro Assays to Monitor Nanoparticle Interaction with Components of the Immune System (Dobrovolskaia MA & Mcneil SE)
Animal Models to Monitor Adverse Effects of Nanomaterials on the Immune System (Smith M et al.)
Understanding Correlation Between In Vitro and In Vivo Immunological Assays for Engineered Nanomaterials (Dobrovolskaia MA & Mcneil SE)

Volume 2: Haematocompatibility of Engineered Nanomaterials:
Interaction with Plasma Proteins as It Relates to Particle Biodistribution (Nienhaus U and Treuel L)
Protein Binding Case Study 1: Understanding Relationship Between Protein Corona and Nanoparticle Toxicity (Dobrovolskaia M et al.)
Mathematical Modeling of Protein Corona and Its Implication in the Design of Nanotechnology-Based Drug Delivery Systems (Cedervall T)
Effects on Erythrocytes (Brown R et al.)
Effects on Endothelial Cells (Simak J)
Effects on Plasma Coagulation (Simak J)
Effects on Platelets (Simak J)
Nanoparticles and Coagulation System: Benefits of Nanotechnology and Safety Considerations (Ilinskaya A & Dobrovolskaia M A)
Complement Activation by Nanomaterials (Salvador-Morales C & Sim R)
Complement Activation Case Study: Induction of CARPA by PEGylated Liposomes (Szebeni J et al.)
Nanoparticles and the Lymphatic System (Khan W and Sistla)

Volume 3: Engineered Nanomaterials and the Immune Cell Function:
Bidirectional Interaction Between Nanoparticles and Carrier-Mediated Agents and Cells of the Mononuclear Phagocytic System (Zamboni W et al.)
Case Study: Application of Leukolike Technology to Camouflage Nanoparticles from the Immune Recognitiont (Tasciotti E et al.)
The Effects of Nanoparticles on Dendritic Cells (Fesenkova V)
The Effects of Nanoparticles on Bone Marrow Cells (Dadacheva E)
Nanoparticles and Vaccine Delivery and Efficacy (Xiang S et al.)
Undesirable Adjuvanticity of Nanoparticles and Its Implication in Modulation of T Helper Responses (Inoue K)
Immunosuppressive and Anti-Inflammatory Properties of Engineered Nanomaterials (Ilinskaya A & Dobrovolskaia MA)
Nanoparticles as Drug Deliveyr Vehicels for the Therapy of Inflammatory Disorders (Menon D et al.)
Application of Nanoparticles for the Delivery of Anti-Viral Drugs (Liptrott N et al.)
Nanostructures and Allergy (Lorenzo-Abalde S & Gonzalez-Fernandez A)
Nanoparticles and Antigenicity (Dobrovolskaia MA)
Nanoparticles and Tumor Immunity Case Study: Application of Iron Oxide Local Hyperthermia Treatment of Tumors Induces CD8+ T Cell-Mediated Resistance Against Distal and Secondary Tumors (Fiering S et al.)

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