戻る / Previous page

  • In Stock
  • Special Price

Series : Springer Series in Statistics

Multiple Testing Procedures and Applications to Genomics, 1st Edition

Multiple Testing Procedures and Applications to Genomics, 1st Edition
Author
Dudoit, Sandrine/ Van Der Laan, Mark J. 
Publisher
Springer-Verlag 
Publication Date
Dec, 2007 
ISBN
0387493166 or 9780387493169
HARDCOVER 
558 Pages
出版済 弊社に在庫ございます。
In Stock

¥ 29,142 (tax included)

Description

This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. The methods are applied to a range of testing problems in biomedical and genomic research, including the identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments, such as microarray experiments; tests of association between gene expression measures and biological annotation metadata (e.g., Gene Ontology); sequence analysis; and the genetic mapping of complex traits using single nucleotide polymorphisms. The book is aimed at both statisticians interested in multiple testing theory and applied scientists encountering high-dimensional testing problems in their subject matter area. Specifically, the book proposes resampling-based single-step and stepwise multiple testing procedures for controlling a broad class of Type I error rates, defined as tail probabilities and expected values for arbitrary functions of the numbers of Type I errors and rejected hypotheses (e.g., false discovery rate). Unlike existing approaches, the procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions (with arbitrary dependence structures among variables), null hypotheses, and test statistics. The multiple testing results are reported in terms of rejection regions, parameter confidence regions, and adjusted p-values.

Contents

1 Multiple Hypothesis Testing
2 Test Statistics Null Distribution
3 Overview of Multiple Testing Procedures
4 Single-Step Multiple Testing Procedures for Controlling General Type I Error Rates, Θ(FVn)
5 Step-Down Multiple Testing Procedures for Controlling the Family-Wise Error Rate
6 Augmentation Multiple Testing Procedures for Controlling Generalized Tail Probability Error Rates
7 Resampling-Based Empirical Bayes Multiple Testing
Procedures for Controlling Generalized Tail Probability Error Rates
8 Simulation Studies: Assessment of Test Statistics Null Distributions
9 Identification of Differentially Expressed and Co-Expressed Genes in High-Throughput Gene Expression Experiments
10 Multiple Tests of Association with Biological Annotation Metadata
11 HIV-1 Sequence Variation and Viral Replication Capacity
12 Genetic Mapping of Complex Human Traits Using Single Nucleotide Polymorphisms: The ObeLinks Project
13 Software Implementation

送料無料にてお届け

ご注文商品は海外からのお取り寄せのため,納期は3~5週間程頂きます。入荷の遅延,出版延期など納期に遅れが見込まれる場合はメールにてお知らせ致します

公費/校費/社費でのお支払い

ご注文の際,お支払方法を選択して頂く画面が表示されますので,「公費/校費/社費」をお選び頂き必要書類をご指定下さい。公費/校費/社費の場合でも、HP掲載価格で承ります。

書籍が見つからない場合

お問い合わせメールより書籍のタイトルや ISBNなど、お手持ちの情報をお知らせ下さい。お見積り、ご注文を承ります。

SSL グローバルサインのサイトシール