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Series : Advances in Experimental Medicine and Biology

Cellular Oscillatory Mechanisms

Cellular Oscillatory Mechanisms
Author
Maroto, Miguel, Ph.D. (EDT)/ Monk, Nick (EDT) 
Publisher
Springer-Verlag 
Publication Date
Oct, 2008 
ISBN
0387097937 or 9780387097930
HARDCOVER 
170 Pages
出版済み 3-5週間でお届けいたします。
The delivery time takes 3 to 5 weeks

¥ 31,978 (tax included)

Description

The chapters in this book provide an introduction to a range of both well known and less familiar cellular oscillations and serve to illustrate the striking richness of cellular dynamics. The contributions focus particularly on elucidating the basic mechanisms that underlie these oscillations. The essentially quantitative nature of oscillations has long made them an attractive area of study for theoretical biologists, and the application of complementary modelling and experimental approaches can yield insights into oscillatory dynamics that go beyond those that can be obtained by either in isolation. The benefits of this synergy are reflected in the contributions appearing in this book. The current resurgence in interest in interdisciplinary approaches to cell and molecular biology stems in part from the increasing availability of system-wide data on the state of the components of cellular regulatory networks. Alimiting factor in these approaches is often the lack of suitable ways of characterising a network state in terms of summary quantitative features. Without such features, it is typically difficult to gain new qualitative insight into the operating logic of all but the simplest networks. In this regard, oscillatory phenomena provide ideal exemplars for systems approaches, since oscillations have clear summary features that prove invaluable in combining mathematical models with experimental data.

Contents

1. CALCIUM OSCILLATIONS; Ruediger Thul, Tomas C. Bellamy, H. Llewelyn Roderick, Martin D. Bootman, and Stephen Coombes Abstract Introduction Modelling Ca2+ Dynamics Mechanistic Models Homogenous Cell Models Threshold Models Stochastic Modelling Concluding Remarks 2. OSCILLATIONS BY THE p53-Mdm2 FEEDBACK LOOP; Galit Lahav Abstract Introduction The p53-Mdm2 Negative Feedback Loop Oscillations of p53 and Mdm2 The Mechanism of p53-Mdm2 Oscillations Variability in the Response of Individual Cells The Potential Function of p53 Oscillations Conclusion and Key Questions in the Field 3. CAMP OSCILLATIONS DURING AGGREGATION OF DICTYOSTELIUM; William F. Loomis Abstract Introduction Proposed cAMP Oscillatory Circuit Periodic Motility Discussion 4. MIN OSCILLATION IN BACTERIA; Joe Lutkenhaus Abstract Introduction Z Ring The Min System The Oscillation Biochemistry of Min Proteins Models Conclusions 5. DEVELOPMENT ON TIME; Isabel Palmeirim, Sofia Rodrigues, J. Kim Dale and Miguel Maroto Abstract Somitogenesis Is a Strict Time-Controlled Embryonic Process Time Control during Somite Formation: The Segmentation Clock The Genetic Complexity Underlying the Segmentation Clock The Clock and Wavefront Model Temporal vs Positional Information Conclusions 6. OSCILLATORY EXPRESSION OF HES FAMILY TRANSCRIPTION FACTORS: INSIGHTS FROM MATHEMATICAL MODELLING; Hiroshi Momiji and Nicholas A.M. Monk Abstract Delay-Driven Oscillations in Cellular Signaling Systems Hes1 as a Cellular Oscillator Mathematical Modelling of the Hes1 Oscillator Properties of Delay-Driven Oscillations Extended Models of Hes1 Regulation Spatio-Temporal Coordination of Oscillatory Dynamics Discussion 7. REVERSE ENGINEERING MODELS OF CELL CYCLE REGULATION; Attila Csiksz-Nagy, Bla Novk and John JTyson Abstract Bottom-Up Modeling and Reverse Engineering Physiology of the Cell Cycle Three Cell Cycle States and Three Cell Cycle Transitions Cell Cycle Transitions and Bifurcation Points Reverse Engineering the Molecular Regulatory Network The Complete Bifurcation Diagram Cell Cycles and Limit Cycles Conclusion 8. MITOCHONDRIAL OSCILLATIONS IN PHYSIOLOGY AND PATHOPHYSIOLOGY; Miguel A. Aon, Sonia Cortassa and Brian ORourke Abstract Introduction The Mitochondrial Oscillator of Heart Cells: The Pathophysiological Domain The Theoretical Approach The Mitochondrial Oscillator in the Physiological Domain Spatial Aspects: ROS and Mitochondrial Criticality From Mitochondrial Dynamics to Whole Heart Arrhythmias Conclusions 9. RESPIRATORY OSCILLATIONS IN YEASTS; David Lloyd Abstract Introduction Minute-Long Oscillations in S. cerevisiae Ultradian (t 30-50min) Oscillations in Synchronous Cultures of Yeasts Schizosaccharomyces pombe Candida utilis Saccharomyces cerevisiae: Self Synchronized Continuous Culture Mitochondrial Respiratory Dynamics in Vivo During Growth Oxidative Stress and Signalling by ROS Circadian Oscillations in Yeasts Other Oscillations Functions of Oscillations 10. STOCHASTIC PHASE OSCILLATOR MODELS FOR CIRCADIAN CLOCKS; Jacques Rougemont and Felix Naef Background Mathematics of Phase Models Theory vs. Data Conclusion

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