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Series : Advances in Experimental Medicine and Biology, 509

Iron Chelation Therapy

Iron Chelation Therapy
Author
Hershko, Chaim (EDT) 
Publisher
Kluwer Academic Publishers 
Publication Date
Dec, 2002 
ISBN
0306467852 or 9780306467851
HARDCOVER 
280 Pages
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¥ 23,279 (tax included)

Description

Within the last few years, iron research has yielded exciting new insights into the understanding of normal iron homeostasis. Such development, and the evolution of improved strategies of Iron Chelating Therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant developments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload. This volume highlights the impact of long term Iron Celating Therapy using deferoxamine or the new, but controversial oral iron chelator deferiprone based on experience gained by multicenter trails, with special emphasis on survival, morbidity and drug toxicity; it reviews the development of the new and improved orally effective chelators suitable for clinical use in the near future and examines novel strategies of iron chelating treatment for the control of cell proliferation in malignant disease or malaria.

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