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Series : NATO CHALLENGES OF MODERN SOCIETY

Perspectives on Biologically Based Cancer Risk Assessment

Perspectives on Biologically Based Cancer Risk Assessment
Author
Cogliano, Vincent James (EDT)/ Luebeck, E. Georg (EDT)/ Zapponi, Giovanni A. (EDT) 
Publisher
Kluwer Academic Publishers 
Publication Date
Jun, 1999 
ISBN
0306461080 or 9780306461088
HARDCOVER 
319 Pages
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¥ 29,137 (tax included)

Description

The book includes a comprehensive updated analysis of cancer risk assessment procedures, with particular attention to biologically-based modelling. The presented arguments include the basic assumptions of cancer risk assessment methods, their biological basis and theoretical background, the relevant data sources, the multistage models (including the two-stage and clonal expansion models and pharmacokinetic models), and the relevant biomarkers, together with fundamental statistical considerations and selected case studies and examples of practical applications. The uncertainty of assessment and the practical use of the proposed methods are also discussed and possible new developments suggested. The book examines in detail the updated biologically-based carcinogenic risk assessment procedures together with the usually employed procedures, as well as background information on which they are based. It also proposes new ideas and methods in this field. Furthermore, it includes criteria and methods for practical application and use of the examined procedures.

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