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Handbook of Cell Signaling, 2nd Edition
細胞シグナリングハンドブック(全3巻)

Handbook of Cell Signaling, 2nd Edition 細胞シグナリングハンドブック(全3巻)
Author
Bradshaw, Ralph A. (EDT)/ Dennis, Edward A. (EDT) 
Publisher
Academic Press 
Publication Date
Sep, 2009 
ISBN
0123741459 or 9780123741455
HARDCOVER 
3,047 Pages
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Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors

Contents

VOLUME 1
Preface to the Second Edition
Preface to the First Edition
1 Cell Signaling: Yesterday, Today, and Tomorrow
PART I
INITIATION: EXTRACELLULAR AND MEMBRANE EVENTS
Section A: Molecular Recognition
2 Structural and Energetic Basis of Molecular Recognition
3 Free Energy Landscapes in Protein-Protein Interactions
4 Molecular Sociology
5 Antibody Antigen Recognition and Conformational Changes
6 Binding Energetics in Antigen Antibody Interfaces
7 Immunoglobulin Fc Receptor Interactions
8 Ig-Superfold and its Variable Uses in Molecular Recognition
9 T Cell Receptor/pMHC Complexes
10 Mechanistic Features of Cell Surface Adhesion Receptors
11 The Immunological Synapse
12 NK Receptors
13 Carbohydrate Recognition and Signaling
14 Rhinovirus Receptor Interactions
15 HIV-1 Receptor Interactions
16 Influenza Virus Neuraminidase Inhibitors
17 Structural Basis of Signaling Events Involving Fibrinogen and Fibrin
18 Structural Basis of Integrin Signaling
19 Structures of Heterotrimeric G Proteins and their Complexes
20 G-Protein-Coupled Receptor Structures
21 Toll-like Receptors Structure and Signaling
22 Variable Lymphocyte Receptors
23 Structure and Function of G-Protein-Coupled Receptors: Lessons from Recent Crystal Structures
24 Chemokines and Chemokine Receptors: Structure and Function
25 The 2 Adrenergic Receptor as a Model for G-Protein-Coupled Receptor Structure and Activation by Diffusible Hormones
26 Protease-Activated Receptors
27 Agonist-Induced Desensitization and Endocytosis of G-Protein-Coupled Receptors
28 Functional Role(s) of Dimeric Complexes Formed from G-Protein-Coupled Receptors
29 Chemotaxis Receptors in Bacteria: Transmembrane Signaling, Sensitivity, Adaptation, and Receptor Clustering
30 An Overview of Ion Channel Structure
31 Molecular Mechanism of Store-Operated Ca2+ Signaling and CRAC Channel Activation Mediated by STIM & Orai
32 Ion Permeation: Mechanisms of Ion Selectivity and Block
33 Nicotinic Acetylcholine Receptors
34 Ion Channels Regulated by Direct Binding of Cyclic Nucleotides
35 Overview of Cytokine Receptors
36 Growth Hormone and Prolactin Family of Hormones and Receptors: The Structural Basis for Receptor Activation and Regulation
37 Erythropoietin Receptor as a Paradigm for Cytokine Signaling
38 The Fibroblast Growth Factor (FGF) Signaling Complex
39 Structure of IFN- and its Receptors
40 Structure and Function of Tumor Necrosis Factor (TNF) at the Cell Surface
41 The Mechanism of NGF Signaling Suggested by the p75 and TrkA Receptor Complexes
42 The Mechanism of VEGFR Activation by VEGF
43 Receptor Ligand Recognition in the TGF Superfamily as Suggested by Crystal Structures of their Ectodomain Complexes
44 Insulin Receptor Complex and Signaling by Insulin
45 Structure and Mechanism of the Insulin Receptor Tyrosine Kinase
46 IL-21 Increased Potency Design
47 Signaling of IL-4R, a Typical Class I Cytokine Receptor: What Defines the Quiescent State?
48 Epidermal Growth Factor Kinases and their Activation in Receptor Mediated Signaling
49 Tumor Necrosis Factor Receptor-Associated Factors in Immune Receptor Signal Transduction
50 Assembly of Signaling Complexes for TNF Receptor Family Molecules
51 Mechanisms of CD40 Signaling in the Immune System
52 Role of Lipid Domains in EGF Receptor Signaling
53 Lipid-Mediated Localization of Signaling Proteins
54 Organization of Photoreceptor Signaling Complexes
55 Transmembrane Receptor Oligomerization

VOLUME 2
PART II
TRANSMISSION: EFFECTORS AND CYTOSOLIC EVENTS
56 Eukaryotic Kinomes: Genomics and Evolution of Protein Kinases
57 Modular Protein Interaction Domains in Cellular Communication
58 Structures of Serine/Threonine and Tyrosine Kinases
59 Protein Tyrosine Kinase Receptor Signaling Overview
60 Signaling by the Platelet-Derived Growth Factor Receptor Family
61 The Epidermal Growth Factor Receptor Family
62 Mechanisms and Functions of Eph Receptor Signaling
63 Cytokine Receptor Signaling
64 The Negative Regulation of JAK/STAT signaling
65 Protein Kinase Inhibitors
66 Integrin Signaling: Cell Migration, Proliferation, and Survival
67 Downstream Signaling Pathways: Modular Interactions
68 Non-Receptor Tyrosine Kinases in T Cell Antigen Receptor Function
69 Receptor Tyrosine Kinase Signaling and Ubiquitination
70 TGF Signal Transduction
71 Mitogen-Activated Protein Kinases
72 Recognition of Phospho-Serine/Threonine Phosphorylated Proteins by Phospho-Serine/Threonine-Binding Domains
73 AMP-Activated Protein Kinase
74 Principles of Kinase Regulation
75 Calcium/Calmodulin-Dependent Protein Kinase II
76 Glycogen Synthase Kinase 3
77 The PIKK Family of Protein Kinases
78 Histidine Kinases in Two-Component Signaling Pathways
79 The EF2K/MHCK/TRPM7 Family of Atypical Protein Kinases
80 The Leucine-Rich Repeat Receptor Protein Kinases of Arabidopsis thaliana a Paradigm for Plant LRR Receptors
81 Engineering Protein Kinases with Specificity for Unnatural Nucleotides and Inhibitors
82 Clinical Applications of Kinase Inhibitors in Solid Tumors
83 Ubiquitin-Mediated Regulation of Protein Kinases in NFκB Signaling
84 Global Analysis of Phosphoregulatory Networks
Section B: Protein Dephosphorylation
85 Phosphatase Families Dephosphorylating Serine and Threonine Residues in Proteins
86 The Structure and Topology of Protein Serine/Threonine Phosphatases
87 Naturally Occurring Inhibitors of Protein Serine/Threonine Phosphatases
88 Protein Phosphatase 1 Binding Proteins
89 Protein Serine/Threonine Phosphatase Inhibitors and Human Disease
90 Calcineurin
91 Protein Serine/Threonine-Phosphatase 2C (PP2C)
92 Approaches to the Identification of Protein Tyrosine Phosphatase Substrates
93 Inhibitors of Protein Tyrosine Phosphatases
94 Regulating Receptor PTP Activity
95 CD45
96 Cell-Cycle Functions and Regulation of Cdc14 Phosphatases
97 MAP Kinase Phosphatases
98 SH2 Domain-Containing Protein-Tyrosine Phosphatases
99 Insulin Receptor PTP: PTP1B
100 STYX/Dead Phosphatases
101 Zebrafish and Phosphatase Function
102 Eyes Absent Protein Tyrosine Phosphatases: a New Eukaryotic Branch of the Haloacid Dehalogenase Superfamily
103 PHLPP: PH Domain Leucine-Rich Repeat Protein Phosphatase
104 PTEN
105 PTP Oxidation
106 Chronophin and Slingshot Cofilin Phosphatases in Cytoskeletal Regulation
107 Large Scale Structural Analysis of Protein Tyrosine Phosphatases
108 Protein Phosphatases and Circadian Clocks
Section C: Calcium Signal Transduction
109 Calcium Signaling; Messengers, Transport Pathways, Sensors, and Physiological Outcomes
110 Phospholipase C
111 Cyclic ADP-ribose and NAADP
112 Voltage-Gated Calcium Channels
113 Store-Operated Calcium Channels
114 Arachidonic Acid-Regulated Ca2+ Channel
115 IP3 receptors
116 Ryanodine Receptors
117 Intracellular Calcium Signaling
118 Calcium Pumps
119 Sodium/Calcium Exchange
120 Ca2+ Buffers
121 Mitochondria as Organizers of the Cellular Ca2+ Signaling Network
122 EF-Hand Proteins and Calcium Sensing: The Neuronal Calcium Sensor Proteins
123 Calmodulin-Mediated Signaling
124 The Family of S100 Cell Signaling Proteins
125 Annexins and Calcium Signaling
126 Calpain
127 Calcium Signaling in Smooth Muscle
128 Calcium Signaling in Cardiac Muscle
Section D: Lipid-Derived Second Messengers
129 Historical Overview: Protein Kinase C, Phorbol Ester and Lipid Mediators
130 Type I Phosphatidylinositol 4-phosphate 5-kinases (PI4P 5-kinases)
131 Type II PIP4-Kinases
132 Phosphoinositide 3-Kinases
133 PTEN/MTM Phosphatidylinositol Phosphatases
134 The Src Homology 2 Containing Inositol 5′ Phosphatases
135 Structural Principles of Lipid Second Messenger Recognition
136 Pleckstrin Homology (PH) Domains
137 PX Domains
138 FYVE Domains in Membrane Trafficking and Cell Signaling
139 Protein Kinase C: Relaying Signals from Lipid Hydrolysis to Protein Phosphorylation
140 Modulation of Monomeric G Proteins by Phosphoinositides
141 Phosphoinositides and Actin Cytoskeletal Rearrangement
142 Phosphatidylinositol Transfer Proteins
143 Inositol Pentakisphosphate: A Signal Transduction Hub
144 Phospholipase D
145 Diacylglycerol Kinases
146 Sphingosine-1-Phosphate Receptors: An Update
147 Lysophosphatidic Acid and Sphingosine-1-Phosphate Activation of G-Protein-CoupledReceptors
148 The Role of Ceramide in Cell Regulation
149 Role of Phospholipase A2 Forms in Arachidonic Acid Mobilization and Eicosanoid Generation
150 Prostaglandin Mediators
151 Leukotriene Mediators
152 Lipoxins and Aspirin-Triggered15-epi-Lipoxins: Pro-Resolving Mediators in Anti-Inflammation and Resolution
153 Protein Proximity Interactions
154 Rapid Characterization of in vivo Phosphorylation Sites and the Protein Kinases and Phosphatases that Regulate them by Affinity Capture
155 FRET Analysis of Signaling Events in Cells
156 The Focal Adhesion: a network of molecular interactions
157 WASP and WAVE Family Protein Complexes
158 Synaptic NMDA-Receptor Signaling Complex
159 Toll Family Receptors
160 Signaling and the Immunological Synapse
161 The Ubiquitin Proteasome System
162 Caspases: Cell Signaling by Proteolysis
163 MAP Kinase in Yeast
164 Mammalian MAP Kinases
165 Subcellular Targeting of PKA through AKAPs: Conserved Anchoring and Unique Targeting Domains
166 AKAP Transduction Units: Context Dependent Assembly of Signaling Complexes
167 Dendritic Protein Phosphatase Complexes
168 Protein Phosphatase2A
169 14 3 3 Proteins
170 Protein Interaction Data Resources
Section F: Cyclic Nucleotides
171 Adenylyl Cyclases
172 Guanylyl Cyclases
173 Phosphodiesterase Families
174 The cAMP-Specific Phosphodiesterases: a Class of Diverse Enzymes that Define the Properties and Localization of cAMP Signals
175 cAMP/cGMP Dual-Specificity Phosphodiesterases
176 Phosphodiesterase-5
177 Function and Regulation of Photoreceptor Phosphodiesterase (PDE6) in the Visual Signaling Pathway
178 Regulation of Cyclic Nucleotide Levels by Sequestration
179 cAMP-Dependent Protein Kinase
180 Cyclic GMP-Dependent Protein Kinase: Targeting and Control of Expression
181 Inhibitors of Cyclic AMP- and Cyclic GMP-Dependent Protein Kinases
182 Substrates of Cyclic Nucleotide-Dependent Protein Kinases
183 Physiological Substrates of PKA and PKG
184 Effects of cGMP-Dependent Protein Kinase Knockouts
185 Cyclic Nucleotide-Regulated Cation Channels
186 Epac, cAMP-Regulated Guanine Nucleotide Exchange Factors for Rap1 and Rap2
187 Cyclic Nucleotide-Binding GAF Domains in Phosphodiesterases and Adenylyl Cyclases
188 Use of Chimeric Adenylyl Cyclases to Study Cyclic Nucleotide Signaling
189 Cyclic Nucleotide Signaling in the Kinetoplastids
190 Cyclic Nucleotide Specificity and Cross-Activation of Cyclic Nucleotide Receptors
191 Cyclic Nucleotide Analogs as Tools to Investigate Cyclic Nucleotide Signaling
192 cGMP and PKG Signaling in Platelets
193 Use of siRNA and Antisense Knockdown to Study the Regulation of PKA by PKI
194 Cyclic Nucleotide Signaling in the Central Nervous System
195 Compartmentation of cAMP in cardiomyocytes
196 Phosphodiesterase-9: a cGMP-Specific Enzyme
Section G: G Proteins
197 Signal Transduction by G Proteins: Basic Principles, Molecular Diversity, and Structural Basis of Their Actions
198 Heterotrimeric G Protein Signaling at Atomic Resolution
199 In Vivo Functions of Heterotrimeric G Proteins
200 Regulation of G Proteins by Covalent Modification
201 G-Protein-Coupled Receptors, Signal Fidelity, and Cell Transformation
202 Signaling through Gz
203 Effectors of Gαo
204 Mono-ADP-Ribosylation of Heterotrimeric G Proteins
205 Specificity of G-Protein Bγ Dimer Signaling
206 The Superfamily of "Regulator of G-protein Signaling" (RGS) Proteins
207 G-Protein Signaling in Chemotaxis
208 Reversible Palmitoylation in G-Protein Signaling
209 G Proteins in Gustatory Transduction
210 Regulation of Synaptic Fusion by Heterotrimeric G Proteins
211 G-protein Regulation of Channels
212 Ras and Cancer
213 The Influence of Intracellular Location on Function of Ras Proteins
214 Role of R-Ras in Cell Growth
215 The Ran GTPase: Cellular Roles and Regulation
216 Regulation of NADPH Oxidases by Rac GTPase
217 The Role of Rac and Rho in Cell Cycle Progression
218 Cdc42 and Its Cellular Functions
219 Tissue Transglutaminase: A Unique GTP-binding/GTPase
220 Roles for ADP-Ribosylation Factors in Membrane Traffic
221 Yeast Small G-Protein Function: Molecular Basis of Cell Polarity in Yeast
222 Farnesyltransferase Inhibitors
223 Structure of Rho Family Targets
224 Structural Features of RhoGEFs
225 Structural Considerations of Small GTP-Binding Proteins
226 Mx Proteins: High Molecular Weight GTPases with Antiviral Activity
Section H: Developmental Signaling
227 Interactions between Wnt/-catenin/Fgf and Chemokine Signaling in Lateral Line Morphogenesis
228 Wnt Signaling in Development
229 Hedgehog Signaling in Development and Disease
230 Regulation of Vertebrate Left-Right Axis Development by Calcium
231 LIN-12/Notch Signaling: Induction, Lateral Specification and Interaction with the EGF/Ras Pathway
232 Proteolytic Activation of Notch Signaling: Roles for Ligand Endocytosis and Mechanotransduction
233 BMPs in Development
234 Neurotrophin Signaling in Development
235 Mechanisms Underlying Context-Dependent VEGF Signaling for Distinct Biological Responses
236 Vascular Endothelial Growth Factors and Receptors: Signaling in Vascular Development
237 Signaling from Fibroblast Growth Factor Receptors in Development and Disease
238 The Role of Receptor Protein Tyrosine Phosphatases in Axonal Pathfinding
239 Attractive and Repulsive Signaling in Nerve Growth Cone Navigation
240 Semaphorins and their Receptors in Vertebrates and Invertebrates
241 Signaling Pathways that Regulate Cell Fate in the Embryonic Spinal Cord
242 Cadherin Regulation of Adhesive Interactions
243 Integration of BMP, RTK and Wnt Signaling through Smad1 Phosphorylations

VOLUME 3
PART III
TRANSCRIPTION AND TRANSLATION: NUCLEAR AND CYTOPLASMIC EVENTS
Section A: Nuclear Receptors
244 Nuclear Receptor Coactivators
245 Corepressors in Mediating Repression by Nuclear Receptors
246 Steroid Hormone Receptor Signaling
247 Role of COUP-TFII in Congenital Diaphragmatic Hernia
248 Nuclear Receptors in Drosophila melanogaster
Section B: Transcription Factors
249 JAK-STAT Signaling
250 FOXO Transcription Factors: Key Targets of the PI3K-Akt Pathway That Regulate Cell Proliferation, Survival, and Organismal Aging
251 The Multi-gene Family of Transcription Factor AP-1
252 NF-KB: a Key Integrator of Cell Signaling
253 Transcriptional Regulation via the cAMP Responsive Activator CREB
254 The NFAT Family: Structure, Regulation and Biological Functions
255 Ubiquitination/Proteasome
256 The SMADs
Section C: Damage/Stress Responses
257 Complexity of Stress Signaling
258 Signal Transduction in the Escherichia coli SOS Response
259 Oxidative Stress and Free Radical Signal Transduction
260 Screening Approaches to Identify Genes Required for DNA Double-Strand Break Damage Signaling in the Yeast Saccharomyces Cerevisiae
261 Radiation Responses in Drosophila
262 Double-strand Break Recognition and its Repair by Non-homologous End Joining
263 ATM-Mediated Signaling Defends the Integrity of the Genome
264 Signaling to the p53 Tumor Suppressor through Pathways Activated by Genotoxic and Non-Genotoxic Stresses
265 The p53 Master Regulator and Rules of Engagement with Target Sequences
266 Nuclear and Cytoplasmic Functions of Abl Tyrosine Kinase
267 Radiation-induced Cytoplasmic Signaling
268 The Heat-Shock Response and the Stress of Misfolded Proteins
269 Hypoxia-Mediated Signaling Pathways
270 Regulation of mRNA Turnover by Cellular Stress
271 Oncogenic Stress Responses
272 Ubiquitin and FANC Stress Responses
273 Stress and -H2AX
Section D: Post-Transcriptional Control
274 Translational Control by Amino Acids and Energy
275 Translation Control and Insulin Signaling
276 ER and oxidative stress: Implications in disease
277 Regulation of mRNA Turnover
278 Signaling to Cytoplasmic Polyadenylation and Translation
279 Translational Control in Invertebrate Development
280 The Role of Alternative Splicing During the Cell Cycle and Programmed Cell Death
281 Signaling Pathways that Mediate Translational Control of Ribosome Recruitment to mRNA
Section E: Chromatin and its Modification
282 The SWI/SNF and RSC Nucleosome Remodeling Complexes
283 ISWI Chromatin Remodeling Complexes
284 The INO80 Chromatin Remodeling Complex
285 Histone Acetylation Complexes
286 Regulation of Histone Deacetylase Activities and Functions by Phosphorylation and Dephosphorylation Edward Seto and Xiang-Jiao Yang
287 Histone Methylation: Chemically Inert But Chromatin Dynamic
288 Histone Phosphorylation: Chromatin Modifications that Link Cell Signaling Pathways to Nuclear Function Regulation
289 Histone Variants: Signaling or Structural Modules?
290 Silent Chromatin Formation and Regulation in the Yeast Saccharomyces cerevisiae
291 Gene Silencing and Chromatin Modification by Polycomb Complexes in Flies and Humans
292 Histone Ubiquitination
293 Chromatin-mediated Control of Gene Expression in Innate Immunity and Inflammation
PART IV
SIGNALING FROM INTRACELLULAR COMPARTMENTS
294 Protein Quality Control in the Endoplasmic Reticulum
295 Quality Control and Quality Assurance in the Mitochondrion
296 Protein Quality Control in Peroxisomes: Ubiquitination of the Peroxisomal Targeting Signal Receptors
297 Mitochondrial Dynamics: Fusion and Division
298 The SREBP Pathway: Gene Regulation through Sterol Sensing and Gated Protein Trafficking
299 Regulating Endoplasmic Reticulum Function through the Unfolded Protein Response
300 Signaling Pathways from Mitochondria to the Cytoplasm and Nucleus
301 Apostosis Signaling: A Means to an End
302 Regulation of Cell Cycle Progression
303 Signaling During Organelle Division and Inheritance: Peroxisomes
304 Signaling at the Nuclear Envelope
305 Bidirectional Cross Talk between Actin Dynamics and Endocytosis
306 Signaling in Autophagy-related Pathways
PART V
CELL-CELL AND CELL-MATRIX INTERACTIONS
307 Overview of Cell Cell and Cell Matrix Interactions
308 Interactive Signaling Pathways in the Vasculature
309 Signaling Pathways Involved in Cardiogenesis
310 Regulatory Signaling in Pancreatic Organogenesis: Implications for Aberrant Signaling in Pancreatic Cancer
311 Trophic Effects of Gut Hormones in the Gastrointestinal Tract
312 The Neurotrophin Factors
313 Cell-Cell and Cell-Matrix Interactions in Bone
314 Cell-Cell Signaling in the Testis and Ovary
315 Signal Transduction in T Lymphocytes
316 Signal Transduction via the B Cell Antigen Receptor: A Crucial Regulator of B Cell Biology
317 Signaling Pathways in the Normal and Neoplastic Breast
318 Kidney
319 Cytokines and Cytokine Receptors Regulating Cell Survival, Proliferation and Differentiation in Hematopoiesis
320 Signaling Pathways Regulating Growth and Differentiation of Adult Stem Cells
321 In Vivo Imaging of Cellular Network Signaling
PART VI
DISEASE PATHOLOGY: TRANSLATIONAL IMPLICATIONS
322 The Roles of Ras Family Small GTPases in Breast Cancer
323 Translational Implications of Stromal-Epithelial Interactions in Prostate Cancer and the Potential Role of Prostate Cancer Stem/Progenitor Cells
324 Aberrant Signaling Pathways in Pancreatic Cancer: Opportunities for Targeted Therapeutics
325 The Evolution and Maintenance of the Multiple Myeloma Cell Clone within the Liquid Bone Marrow Compartment: Therapeutic Implications
326 The Pathophysiologic Role of the Bone Marrow Environment and its Niches in Multiple Myeloma
327 Signaling Targets in Myeloid Leukemias
328 Signaling Targets in Lymphoid Leukemias
329 Targeting Ras for Anti-Cancer Drug Discovery
330 Targeting EWS/FLI1-Driven Signaling Pathways as Therapy for Tumors of the Ewing's Sarcoma Family
331 IRS-Protein Scaffolds and Insulin/IGF Action in Central and Peripheral Tissues
332 Adipokine Signaling: Implications for Obesity
333 Angiogenesis Signaling Pathways as Targets in Cancer Therapy
334 Pulmonary Fibrosis
335 Systemic Sclerosis
336 Signal Transduction in Rheumatoid Arthritis and Systemic Lupus Erythematosus
337 Translational Concepts in Vasculitis
338 Advances in Understanding the Pathogenesis of Inflammatory Bowel Disease
339 Translational Implications of Proteomics
340 Translational Implications of microRNAs in Clinical Diagnostics and Therapeutics

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